My current line of defense against computer threats

Depending on which of the 3 computers I am currently working on, on any given day I have several different programs running to protect my computers.

One of my computers at work has the antivirus software McAfee. http://www.mcafee.com/us/
This same computer also runs Ad-Aware and has a firewall and has the Internet Explorer security zones set to a very high level.

My other computer at work has the antivirus software Vipre. http://www.sunbeltsoftware.com/home-home-office/vipre/
This computer also runs Ad-Aware and has the same firewall and Internet Explorer security zones.

My personal computer at home has the antivirus software NOD32. http://www.eset.com/
This computer also runs Ad-Aware. For the last few months we have been visiting housecall http://housecall.trendmicro.com/ since my teenage son downloaded a little virus.

With the three different antivirus I use on a daily basis at this time I prefer Vipre. Vipre has not locked up my computer while updating its definitions which is something that happens consistantly with McAfee.

I feel I am pretty secure with all the security that we have implemented on our computers. But with the virus a few months ago I know the only true security is knowledge.